quinta-feira, 27 de maio de 2021

Cummings: What happened and what impact will it have? - BBC Newsnight


Former Aide to Boris Johnson Describes Chaos and Incompetence in Britain’s Covid Response

 

May 27, 2021, 1:55 a.m. ET

https://www.nytimes.com/live/2021/05/26/world/covid-vaccine-coronavirus-mask

 

Dominic Cummings tells lawmakers that the prime minister suggested that a doctor inject him with the coronavirus on live television. The F.D.A. approves a third antibody treatment for people with high-risk Covid.

 

 

LONDON — Dominic Cummings, the former top aide to Prime Minister Boris Johnson of Britain, on Wednesday painted a picture of chaos, incompetence and confusion at the heart of the government in a ferociously critical account of its early handling of the Covid-19 pandemic.

 

Testifying before lawmakers, Mr. Cummings said that Mr. Johnson had initially regarded Covid-19 as a “scare story” and at one point had suggested that a doctor inject him with the coronavirus on live television to play down the dangers to a worried public.

 

The prime minister was being advised by a health secretary, Matt Hancock, whom Mr. Cummings accused in his testimony of lying repeatedly, being unworthy of the health care workers he directed and presiding over the deadly transfer of elderly patients from hospitals to nursing homes, many of them carrying the virus.

 

And as the pandemic closed in on Britain, Mr. Johnson was distracted, his former aide said, by an unflattering story about his fiancée and her dog.

 

“When the public needed us most, the government failed,” said Mr. Cummings, the political strategist who masterminded Britain’s campaign to leave the European Union and engineered Mr. Johnson’s rise to power before falling out bitterly with his boss and emerging as a self-styled whistle-blower.

 

Mr. Cummings testified for more than seven hours, in a scene with few precedents in British politics: an unelected aide who had been arguably the nation’s second-most powerful man, offering an unfiltered look at the inner workings of the British government as it confronted the greatest national emergency since World War II.

 

“The problem in this crisis was very much lions led by donkeys, over and over again,” Mr. Cummings said.

 

Mr. Johnson, who was hospitalized with a severe case of Covid-19 in April 2020, flatly rejected several of the assertions of his former aide in his own appearance on Wednesday in Parliament, where lawmakers are trying to determine how the early days of the pandemic were botched so badly.

 

Mr. Cummings, 49, did not absolve himself of all blame. He admitted he had not been open about the reasons for a much-criticized road trip he made with his family that breached lockdown rules. And he acknowledged his mistake in not pushing the prime minister to lock down the country earlier than he did, in March of last year.

 

“Yes, it was a huge failing of mine,” Mr. Cummings told a joint meeting of Parliament’s Science and Technology Committee and Health and Social Care Committees. “I bitterly regret that I did not hit the emergency panic button earlier than I did.”

 

The Food and Drug Administration on Wednesday authorized a monoclonal antibody drug developed by GlaxoSmithKline and Vir as the third treatment of its kind cleared to help keep high-risk Covid patients out of the hospital.

 

In laboratory tests the newly authorized drug, known as sotrovimab, has been able to neutralize the virus variants first identified in Britain, South Africa, Brazil, California, New York and India. The federal government, which has so far purchased the other antibody treatments given to Covid patients in the United States, has not announced any plans to purchase the new drug.

 

GSK has been in conversations with the United States government and is “working through existing commercial channels to make sotrovimab available to patients and health systems in need,” said Kathleen Quinn, a company spokeswoman.

 

The company said in a news release that it expects the drug to become available in the U.S. “in the coming weeks.”

 

The new treatment may offer an advantage as concerns rise about new virus variants that may evade some antibody drugs.

 

The federal government has paused shipments of one antibody treatment on the market, a cocktail of two drugs from Eli Lilly, to eight states because of the high prevalence there of the variants first seen in South Africa and Brazil. Lab experiments suggest those variants can resist Lilly’s treatment. (The other available antibody treatment, a cocktail of two drugs from Regeneron, appears to  neutralize the array of variants, based on lab tests.)

 

GSK and Vir’s treatment is a single drug, designed to mimic the antibodies generated naturally when the immune system fights off the coronavirus, like those detectable after someone infected with it recovers. Its authorization was based on a study of 583 volunteers who had started experiencing symptoms within the previous five days. The study found that those who got the GSK-Vir treatment showed an 85 percent reduction in their risk of hospitalization or death, compared with those who got a placebo.

 

Even as vaccination numbers rise and infection rates fall in the United States, the antibody treatments are likely to remain an important tool for preventing bad outcomes in high-risk patients, doctors say. Thousands of people in the United States are still testing positive, and hundreds dying, each day.

 

Last week the F.D.A.  broadened the criteria that doctors can use to determine eligibility for the treatment, opening the door for more young people with certain medical conditions like hypertension, and members of racial or ethnic groups considered to be at higher risk than others for bad medical outcomes.

 

“Ultimately, it gives prescribers a lot of latitude in what they can give this for,” said Dr. Walid F. Gellad, who directs the Center for Pharmaceutical Policy and Prescribing at the University of Pittsburgh.

 

But the drugs from Lilly and Regeneron have not been used as widely as expected for a range of reasons, according to public health experts.

 

The antibody drugs are all cumbersome to administer. Patients often don’t know to ask for them or where to find them. And many doctors were skeptical of the evidence supporting the treatments when they first became available last November, though that has changed as more clinical trials have reported impressive results.

 

“There’s still a role for these,” Dr. Gellad said. “The problem is just people aren’t getting them who could benefit from them, and having another one on the market doesn’t necessarily solve that.”

 

GSK and Vir’s treatment, like the other antibody drugs, must be administered via intravenous infusion by a health-care provider, which will make it harder to access. The drug makers are testing a formulation injected intramuscularly, like a vaccine, but that is not expected to be available soon.

 

— Rebecca Robbins


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